We work on fundamental questions in biology that are best addressed by genomic approaches.
There are thee projects in the lab right now:
Genome-wide regulatory polymorphisms that affect embryogenesis and species divergence, where we take advantage of the powerful genetics and developmental biology of the mouse.
Cancer evolution from the first proliferative lesions to invasive carcinoma, where we apply principles of molecular evolution to the analysis of somatic variation as it arises during tumor progression.
The interaction of gene regulation with molecular evolution, extending the work from our studies as part of the ENCODE consortium (see the 2012 papers).